Search for: [Abstract = "ast dose of cerulein.The second series of studies were performed to evaluate the effect of obestatin administration on the course of acute pancreatitis. Obestatin was administered twice a day at the dose of 8 nmol\/kg\/dose\; starting the first dose 24 h after the last injection of cerulein. Severity of acute pancreatitis was examined 1 h after the last dose of cerulein or after 1, 2, 3, 5, 7 or 10 days after the last injection of cerulein. \; Results\: The first series of studies has shown that morphological features of pancreases obtained from animals treated with obestatin before induction of acute pancreatitis, exhibit the decrease in pancreatic edema, pancreatic leukocyte infiltration and vacuolization of acinar cells. These effects have been accompanied by a reduction in the pancreatitis\-evoked increase in serum level of pancreatic digestive enzymes, lipase amylase and poly\-C ribonuclease. Also serum concentration of pro\-inflammatory interleukin\-1β was decreased. The pancreatitis\-evoked decrease in pancreatic blood flow and pancreatic DNA synthesis was partially reversed.The second series of study has shown that administration of cerulein has led to the development of acute oedematous pancreatitis in all rats and maximal severity of this disease was observed 24 h after the last dose of cerulein. Treatment with obestatin reduced morphological signs of pancreatic damage such as"]

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