Search for: [Abstract = "antagonistic activity of the TRPA1 channel. Among others, the length of the aliphatic chain and its branching, the type of substituent in the amide and hydrazide moieties, introduction of an additional amino or alkoxy substituent, and replacement of 1,3\-dimethyl\-3,7\-dihydro\-1H\-purine\-2,6\-dione with a 1H\-benzimidazole system were assessed. For representative novel TRPA1 channel antagonists from the group of amide \(compounds 94 and 102\; series IIIa\) and hydrazide \(compounds 142 and 143\; series IIIb\) derivatives of 1,3\-dimethyl\-3,7\-dihydro\-1H\-purine\-2,6\-dione, a potential binding mode to the TRPA1 ion channel was determined using molecular modeling. The obtained results allowed to draw conclusions regarding the structural requirements for this class of antagonists, ensuring optimal binding with this biological target. Based on the results of in vitro tests, the most promising compounds 94 and 102, with stronger antagonistic activity than the HC\-030031 were selected for in vivo pharmacological study in order to confirm the analgesic and anti\-inflammatory properties. In the second \(inflammatory\) phase of the formalin test, compounds 94 and 102 showed stronger analgesic activity than that of HC\-030031. Compounds 94 and 102 revealed antiallodynic properties in oxaliplatin\-induced neuropathic pain model. In the von Frey test, the analgesic activity of the tested compounds was compara"]

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