Search for: [Abstract = "an important factor responsible for the pathogenesis and progression of diabetic autonomic neuropathy in patients with T1DM. The importance of inflammation, confirmed by elevated levels of the Il\-6 marker in the pathomechanism of autonomic neuropathy of the cardiovascular system, has also been demonstrated in patients with properly treated type 1 diabetes. 4. Epigenetic mechanism in search for the pathomechanism of diabetic neuropathy development in diabetes mellitus type 1 \(T1DM\). Gastoł J, Kapusta P, Polus A, Pitera E, Biela M, Wołkow P, Pawliński Ł, Kieć\-Wilk B. Endocrine. 2020 Apr\;68\(1\)\:235\-240. doi\: 10.1007\/s12020\-019\-02172\-9. Epub 2020 Jan 4. \(original work\) The study enrolled 24 patients with T1DM\+CAN, 25 patients with T1DM\-CAN, and 25 healthy volunteers. Single\-center study, homogeneous group of patients \(T1DM\) treated with intensive insulin therapy. Diagnostics for CAN were performed using a battery of Ewing tests \(ProSciCard\). The DNA material was obtained from fasting venous blood samples, then bisulfonated and hybridized using Infinium Methylation EPIC Kit, Illumina and imaged with Illumina HiScan. Changes in the expression of selected genes were verified using qRTPCR. Amplification was carried out using continuous fluorescence detection 7900 HT Fast Real\-Time PCR system \(Thermo Fisher Scientific\). The clinical characteristics of the study population showe"]

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