Search for: [Abstract = "Zinc, a divalent metal, is involved in a myriad of cellular processes, ranging from interactions with zinc\-finger proteins and protein kinases to modulation of synaptic neurotransmission. It is possible that zinc function is linked to the mental function. It seems to be especially important in zinc deficiency in the context of psychiatrie diseases, such as anxiety and depression. Recent data indicated that zinc is implicated in pathophysiology of depression and the mechanism of action by antidepressant drugs. Preclinical studies showed the antidepressant\-like activity of zinc in tests and models of depression. The greatest concentration of zinc sequestring glutamatergic neurons is localized in structures, such as hippocampus and cortex, in which progressive morfological changes are beeing observed during depression ilness. Zinc modulates responses from NMDA receptors\; protect on this way neurons from excessive activity. It also affects the BDNF expression and indirectly neurogenesis and synaptic plasticity. However, the exact zinc antidepressant mechanism of action remains unknown. The aim of this study was to investigate the mechanism of antidepressant zinc activity. Experiments were carried out by using both\: biochemical \(radioligand binding assay\) and behavioral \(forced swim test\) methods. Experiments were directed on glutamateric, serotonergic and adrenergic systems."]
