Search for: [Abstract = "Type 2 diabetes mellitus is associated with an unfavorable fibrin clot phenotype, characterized by a faster formation of more compact fibrin networks, which are less susceptible to lysis \(hypofibrinolysis\) when compared with patients without diabetes. The mechanisms involved are only partially understood. My dissertation aimed to identify novel factors modyfing properties of fibrin and efficiency of fibrinolysis in patients with type 2 diabetes mellitus. There were three cross\-sectional studies, one observational study and one in vitro study. The glycated hemoglobin, hemostasis parameters, platelet activation markers, thrombin generation along with fibrin clot permeability, were investigated. Fibrinolysis efficiency was assessed using three methods, by Lisman et al. \(2001\), Carter et al. \(2007\) and Pieters et al. \(2018\). The first investigated factor was plasma protein oxidation. Three markers were assessed\: total plasma carbonylation, concentration of thiobarbituric acid reactive substances and total antioxidant capacity. The total protein carbonylation was shown to associate with the glycated hemoglobin, time since diabetes diagnosis and concomitant cardiovascular disease. Total plasma carbonylation correlated positively with clot lysis time assessed according to Lisman et al., and negatively with clot permeability. Increased total plasma carbonylation \(in top qua"]

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