Search for: [Abstract = "This study is concerned with relationship between serum level of IGF\-1 and heart function in pts with first STEMI treated with primary angioplasty. The prospective study consisted of 50 pts \(34 men and 16 women\) aged 34\-72 yrs \(mean 56.3±10.8 yrs\) with acute STEMI treated with PCI. Mean follow\-up was 102±8days. The heart function was assessed on 1st day of STEMI \(Killip classification\) and after 3 months follow\-up \(NYHA classification\). Heart function was measured by using echocardiography. The exercise capacity was assessed by cardiopulmonary exercise test. The mean value of IGF\-1 concentration was significantly higher 12 hrs after PCI as compared to the mean value obtained 3 hrs after PCI. There were no correlations between IGF\-1, IGFBP\-3 and CK, CK\-MB, TnI. Significant positive correlations were detected between IGF\-1 and TAPSE on 3rd day of STEMI, between IGF\-1 and LVMI after 3 months follow\-up. Moreover significant positive correlations were observed between IGF\-1 and VO2peak , and between IGF\-1 and VO2\(AT\) after 3 monts follow\-up. The analysis showed in close relationship between type of infarcted coronary artery and heart function. Increase of IGF\-1 concentration in acute STEMI treated with PCI by 70 units leads to improvment in NYHA classification by one class after 3 months follow\-up and increase of NTproBNP concentration by 2500 units leads to worsening of NYHA classi"]

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