Search for: [Abstract = "This monography consists of the two publications concerning theprognostic impact of translocations involving MAF\(musculoaponeurotic fibrosarcoma\) genes, namely translocationst\(14\;16\) and t\(14\;20\) in newly diagnosed multiple myeloma patients.The aim of this retrospective study was to present the clinicalcharacteristics and survival outcomes on a large group of patients withthose translocations. 254 patients with MM diagnosed betweenOctober 2005 and January 2018, testing positively for t\(14\;20\) ort\(14\;16\) were identified from the medical records at 29 participatinginstitutions all over the world. For t\(14\;16\) the median PFS was 24.9months and median OS was 49.0 months\; for t\(14\;20\) median PFSwas 16.6 months and median OS was 54.0 months. In conclusion, bothtranslocations seem to have a similar implication for prognosis inaddition to their similar mechanism. The t\(14\;20\) should beconsidered as an adverse factor of equal prognostic implication as thet\(14\;16\) abnormality in the staging systems. Myeloma patients withMAF translocations who received double ASCT display superior OSin this retrospective dataset."]

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