Search for: [Abstract = "This doctoral dissertation presents the examination of the association between polymorphisms of paroxonase \( PON1\) gene and ATP\-dependent Calcium pump of the endoplasmic reticulum SERCA2a \(ATP2A2\) gene promotor areas. Paroxonase \( PON1\) is an essential component of HDL fraction of serum lipoproteids providing antioxidant activity and therefore preventing production of free radicles and oxidative modification of lipoproteids \( including LDL fraction\). That is one of the essential mechanisms that curb coronary atherosclerosis. The main role of SERCA2a transporter is to restore the low calcium level during cardiomyocyte relaxation immediately so as to make the next cardiac\-muscle contraction hemodynamically effective. Based on studies, a hypothesis has been formulated indicating that polymorphisms in these genes may be correlated with incidence of ventricular arrhytmias in the course of advanced coronary heart disease \( CHD\) \( peri\-infarction period and postinfarct phase\). An increase in intracellular calcium level has a positive inotropic action and the relationship between PON\-1 gene polymorphism and progression of atherosclerosis has been proved and shown to be a risk factor of CHD. The study included 60 patients with CHD who were divided into 2 separate groups according to presence or lack of ventricular arrhytmias. A number of investigations has been conducted to examine a"]

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