Search for: [Abstract = "Thirty\-two AS patients and 32 controls were included in the finalanalysis\; one subject from each group was excluded due to elevated blood white cell count and hypothyroidism respectively. Slightly lower hematocrit, hemoglobin, platelet count and more common hypercholesterolaemia were observed in AS patients, while other routine laboratory parameters were similar in both groups.The indices of the AS severity were\: peak aortic velocity \(Vmax\)=3.8±0.59 m\/s\; peak pressure gradient \(PPG\)=59.4±19.8 mmHg\; mean pressure gradient \(MPG\)=35.4±14.1 mmHg\; aortic valve area \(AVA\)=1.08±0.23 cm2\; AVA indexed to body surface area \(AVA\/BSA\)=0.58±0.1 cm2\/m2. Bicuspid aortic valves were found in 12 \(37.5%\) AS patients.The duration of stress test was shorter in AS group \(p=0.008\) and maximum workload was lower \(p=0.002\) and reached 81.3±21.1 W. During stress test 7 \(21.8%\) patients had dyspnea and 3 \(9.3%\) had angina without echocardiographic signs of ischemia in AS patients, while in the control group 5 patients had dyspnea \(15.6%\). In the AS group at maximum workload PPG rose to 75.3±26.1 mmHg, MPG to 45.3±15.9 mmHg and EF to 73±6.5% \(all p<0.05\). There was no intergroup difference in post exercise increase in EF.There was no differences in baselins levels of Cmax, F1\+2 and TFPI between the two groups. Cmax during peak workload in AS group increased by 25% \(p<0.001\) and was higher than in controls \(p<0.001\). Interestingly, Cmax in AS patients reached its peak 24 hours after exercise, while it followed a different pattern in controls, i.e. it decreased reaching its nadir 24 hours post exercise \(p<0.001\).Baseline plasma sCD40L was similar in both groups without any exercise\-related changes.Baseline CLT was 13% longer among AS patients \(p=0.006\) compared with controls. CLT remained unaltered at peak exercise in AS group and it decreased in controls \(intergroup difference of 28%, p<0.001\). One hour after exercise test CLT decreased in AS patients to the level similar to the control group, and then increased 24 hours later, being 15% higher than in controls \(p<0.001\). Exercise showed no effect on D\-dimer in either group."]

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