Search for: [Abstract = "The working hypothesis was\: angiotensin \(1\-7\) agonist, AVE 0991 could ameliorate the development of atherosclerotic lesions in apolipoprotein E \(apoE\) \- knockout mouse \(apoE\-KO\). 50 female 8\-week\-old apoE–KO mice on C57BL\/6J background were studied. Experimental groups received the same diet as control, mixed with\: AVE 0991 in a dose of 0,58 mol\/kg b.w.\/day, perindopril in a dose of 0,4 mg\/\/kg b.w.\/day and with tiorphan in a dose of 2,5 mg\/\/kg b.w.\/day. A\-779 was given in a dose of 3,3 mg\/kg b.w, 3 times a week i.p. Measured by “en face” method, the percentage of occupied by Sudan IV – stained surfaces were\: 14.6 ± 2.1% in control group, whereas in AVE 0991 treated group 7.63±1.6%, in perindopril group 2.6 ± 0.5%, in tiorphan group 16.7 ± 2.8%, and in A\-779 group 19.2 ± 0.6%. All the differences, except tiorphan were statistically significant. Measured by “cross\-section” in 8 consecutive sections mean surfaces±SEM, occupied by oil Red \- O stained changes were\: 91 416 ± 8 357 m2 in control group versus 47 235 ± 7 546 m2 in AVE 0991 – treated group, 37 107 ± 2 824 m2 in perindopril group, 107 599 ± 9 735 m2 in tiorphan group, and 124 201 ± 10 373 m2 in A\-779 group. All the differences, except tiorphan were statistically significant. To our knowledge, this is the first report that shows the effect of angiotensin \(1\-7\) receptor agonist\: AVE 0991, on atherogenesis in apoE–knoc"]

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