Search for: [Abstract = "The treatment of chronic pain, e.g. neuropathic pain with currently available analgesics is not fully effective. Moreover, these drugs possess numerous side effects and have the potential to lead dependence. The search for safe and non\-addictive analgesics with a new mechanism of action is one of the challenges of modern pharmacotherapy. TRPA1 channel antagonists that blocking the pain peripherally are considered one of the promising strategy for the treatment of neuropathic pain. The aim of the present thesis was to design and synthesize novel amide and hydrazide derivatives of 1,3\-dimethyl\-3,7\-dihydro\-1H\-purine\-2,6\-dione and 1H\-benzimidazole, and to determine their antagonistic activity against the TRPA1 channel in vitro. Compounds with this mechanism of action may be effective in the treatment of chronic pain, including neuropathic pain and inflammatory conditions. A library of 135 compounds belonging to the amide and hydrazide derivatives of 1,3\-dimethyl\-3,7\-dihydro\-1H\-purine\-2,6\-dione 7˗26 \(series Ia\) and 123˗134 \(series Ib\) and 8\-amino\- and 8\-alkoxy\-1,3\-dimethyl\-3,7\-dihydro\-1H\-purine\-2,6\-dione 51˗78 \(series IIa\), 93˗119 \(series IIIa\), 136˗139 \(series IIb\) and 141˗143 \(series IIIb\), as well as 1H\-benzimidazole 150˗170 \(series IVa\) and 181˗192 \(series IVb\) and 2\-piperydyno\-1H\-benzimidazole 174˗177 \(series Va\) and 194˗197 \(series Vb\) was designed by structural modification o"]

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