Search for: [Abstract = "The study demonstrates the non\-invasive and selective delivery of a gene of human vascular endothelial growth factor \(VEGF\) using non\-viral vector \(plasmid\) to rat myocardium using ultrasound targeted microbubbles destruction techinque \(UTMD\). Expression of delivered gene was restricted to the UTMD targeted organ. There was a significant increase in arteriolar density in animals, that received control plasmid with luciferase gene. This finding is probably due to non\-specific effects of UTMD on microcirculation and expression of genes that promote arteriogenesis. The exact molecular mechanism of this phenomenon together with the impact of UTMD\- stimulated arteriogenesis on coronary blood flow remains to be determined."]

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