Search for: [Abstract = "The study aimed to evaluate the safety and effectiveness of the transcatheter closure of ASD Material and methods 35 subjects \(23F, 12M\; mean age\: 42.7 ± 12.7\) were analysed. The control group comprised 19 healthy volunteers. In all pts before and after procedure\: clinical study, transthoracic echocardiography, 24h, cardiopulmonary exercise tests \(CET\), determination of Endothelin 1 \(ET1\) level ECG monitoring were repeated. Results\: The ASO devices were successfully implanted in all subjects. There was improvement of NYHA and CET parameters after 6 and 12 m\-ths \(pts up to 40 y benefited more\). The increase in the number of supraventricular ectopy \(SVE\) was noted 1 month after the procedure with a regression in within the follow\-up. 1 month after the procedure decrease of right heart dimension were observed. ET1 levels in subjects with ASD were higher than in the healthy pts. There was a significant decrease of ET1 level within 48 hours after ASD closure. Conclusions\: 1. Transcatheter closure of ASD is a safe and effective procedure and caused significant improvement of haemodynamic parameters and overall clinical status. It resulted in a improvement of exercise capacity as early as 6 months after the procedure and younger pts benefited more. 2. The procedure is associated with a transient increase in supraventricular premature beats in the early follow\-up. There is a re"]

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