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Search for: [Abstract = "The results\: On the basis on my first stage I analyzed 1846 unique cosmetic products and singled out 336 unique cosmetic ingredients \(which fulfill at least one out of four functions\: preservatives, fragrances, colorants or UV filters\) for which ones I did the systematic review \(II stage\). The most common cosmetic ingredients, fulfilled one of these functions were\: limonene \(in 35,2% leave\-on products and 40% rinse\-off\), linalool \(38,1% leave\-on and 43,7% rinse\-off\), phenoxyethanol \(54% leave\-on\; 19,2% rinse off\), sodium benzoate \(13,18% leave\-on\; 45,6% rinse\-off\), methylisothiazolinone \(16,7% leave\-on\; 42,5% rinse\-off\) as well as methylchloro\/methylisothiazolinone mixture \(9,6% leave\-on\; 40% rinse\-off\). In the second stage on the basis on systematic review I obtained 117 publications which were the source of epidemiological data. What is more I did the metaanalysis for the 69 substances. The most frequently sensitizing substances turned out\: fragrance mix I \(sensitizing 9% in the population with eczema\), fragrance mix II \(sensitizing 5,1% in the population with eczema\), methylisothiazolinone and methylchloro\/methylisothiazolinone mixture \(respectively 3,1% and 2,9% in the population with eczema\). In the third stage I undertaken an attempt to analysis the correlation between the exposure to allergic ingredients and theZał. nr 1 do § 2 zarządzenia nr 45Rektora UJ z 12 czerwca 2006 rokufrequency of allergy to them \- it didn’t prove the existing correlation. An interested it turned out a frequent use of limonene in 48,8% and linalool in 52% examined leave\-on cosmetic products and two preservatives \- methylisothiazolinone and methylchloro\/methylisothiazolinone mixture \(correspondingly presence in 42,5% and 40% rinse\-off cosmetics\) with a high incidence of allergic reactions to those four substances, each of them allergenic about 3% of the population with eczema.Conclusions\: The most frequent in cosmetics fragrance ingredients with known allergic potential are limonene and linalool, and the most common preservatives are phenoxyethanol, sodium benzoate, methylisothiazolinone \(MI\) and methylchloro\/methylisothiazolinone mixture \(MCI\/MI\). The most frequently sensitizing substances are fragrances – in particular fragrance mix I and fragrance mix II \(sensitizing every tenth and twentieth of person in the population with eczema\), while among preservatives attention should be paid to MI and MCI\/MI. Carried out an attempt to analysis the correlation, shows that there is no simple relationship between the prevalence of cosmetic ingredients in cosmetics and the incidence of allergies to those ingredients. This could be partly be due to the fact that the data comes from different geographic areas and different periods of time. Moreover it can be also caused the existence of additional factors not included in this analysis. However studies show that cosmetics are a frequent source of sensitizing haptens."]

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