Search for: [Abstract = "The obtained results were analysed using computer assisted statistic tests\: randomised, based on constant model bifactor analysis taking into account the complete model – with two direct effects \(time effect, group effect\) and the primary interaction effect \(time\/group effect\), Chi squared and Q Cochrane. Statistically significant differences were qualified by a significance level of p<0.05. In the obtained results the percentage of patients with gastrointestinal signs \(clinical and in history\) in both studied groups was similar. Clinical signs during acute alcohol poisoning and withdrawal syndrome did not correlate with the degree of intensification of gastrointestinal mucosa, macro and microscopic lesions and with presence of Helicobacter pylori and smoking. The percentage of smokers and Helicobacter pylori infection in both study groups was similar but significantly higher than in the general Polish population. On gastrofiberoscopy in 24% of all study patients normal gastric mucosa was found and this percentage was identical in both groups. In the other patients primarily 1 degree changes dominated and 2 degree changes were also found \(no 3 degree changes were found\). Changes in the distal parts of the stomach \(antrum and pylorus\) were found twice as often. Both groups did not significantly differ in gastrofiberoscopy in any part of stomach topography during the first as well as control gastrofiberoscopy, no significant changes were found on gastrofiberoscopy in macroscopic dynamic change of the gastric mucosa. On histopathology chronic inflammation of the gastric mucosa was found in all topographic sites in all patients. Similarly to gastrofiberoscopy histologically both groups were dominated by first and second degree lesions which were assessed using the following parameters\: intensity of inflammation, activity, atrophy and intestinal metaplasia. In both groups significant changes in the average degree of corpus gastric mucosa inflammation were not found. In the group of patients with acute alcohol poisoning a significantly higher degree of antral and pyloric gastric mucosa inflammation intensity and of inflammatory activity of the gastric mucosa of the corpus and pylorus as compared to the withdrawal syndrome group was found. No significant differences were found between groups in the average level of gastric mucosa atrophic changes in each particular topographic site, however the average level of intestinal metaplasia was significantly higher in the gastric mucosa of the corpus in the group of patients with acute alcohol poisoning. In follow up gastrofiberoscopy after controlled abstinence the group differences in the degree of antral gastric mucosa inflammation decreased due to the fact that in the withdrawal syndrome group the indicator of average gastric mucosa inflammation increased in control gastrofiberoscopy. An opposite interaction was found in the pyloric gastric mucosa where the average indicator of pyloric inflammation in the withdrawal syndrome group significantly decreased in comparison the group of acute alcohol poisoning patients. In the case of analysis of the indicator of mean inflammatory activity a significant interaction was observed only in the corpus gastric mucosa. In the group with withdrawal syndrome the inflammatory activity of the gastric corpus mucosa decreased over time while in the acute alcohol poisoning group this activity rose over time. Also significant changes were between groups were found in atrophic lesion dynamics and metaplastic lesions of the gastric corpus and pyloric gastric mucosa. In the acute alcohol poisoning group atrophic lesions of the pyloric gastric mucosa increased over time while in the withdrawal syndrome group these lesions decreased over time. In the case of the pylorus in both groups a significant decrease in the indicator of gastric mucosal atrophy over this time was found. In the case of intestinal metaplasia a significant decrease in the indicator of average"]

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