Search for: [Abstract = "The most unfavorable prognostic factors in NB are\: age over the 1year at diagnosis, an advanced disease stage according to INRGSS, anunfavorable tumor histopathology, MYCN gene amplification andstructural chromosomal aberrations. The bone marrow examination forthe presence of NB cells is also crucial step. The presence of thesefactors is the basis of patient’s including in high risk group.The results of this study showed high sensitivity of QRT\-PCRtechniques for the detection of tumor cells in the bone marrow ofpatients with NB using TH and PHOX2B genes as potential molecularmarkers. The PHOX2B gene was the most specific molecular marker.The usefulness of QRT\-PCR techniques for peripheral blood analysisof patients with NB requires further study. It was found lower thanexpected prevalence of structural chromosomal aberrations prognosticin NB, including MYCN amplification. Furthermore, with anunexpectedly high frequency \(37,5%\) it was showed the presence of2p gain. To estimate the exact incidence of 2p gain in Polish patientswith NB and the relationship of this aberration with known prognosticfactors requires further study."]

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