Search for: [Abstract = "The material includes 105 children treated for severe thermal injuries in Division of Plastic and Reconstructive Surgery and Burns, University Children’s Hospital of Cracow \(Chair and Department of Pediatric Surgery, Polish\-American Institute of Pediatrics, Collegium Medicum, Jagiellonian University\) and Pediatric Burn Center in the years 1996\-2005. The thesis is a retrospective, descriptive and comparative analysis. The data of patients treated in the above\-mentioned period were analyzed from the epidemiological and clinical viewpoint. The author gave a detailed description of the dynamic process of development, spread and increase of complexity in colonization and infections of burn wounds in the experimental group, as well as the dependence of microbiological flora on the age of the patient, body surface area and depth involved by the burn, the time interval after the injury and therapeutic modalities. The analysis was performed in 1327 microbacteriological cultures, including 457 cultures of material originating from burn wounds, 429 blood cultures, 215 urine cultures and 226 cultures of material from the endotracheal tubes. The statistical analysis was based on descriptive statistical functions. Qualitative or quantitative data grouped into classes were compared employing χ2–based tests \(the χ2 and its modifications – the Fisher’s exact test and the χ2 test with Yates’ modification\), as well as the Kendall\-tau coefficient. Two\-sided tests were used. Having performed the tests of distribution normality for continuous data, the author employed methods of non\-parametric statistical analysis. The significance of inter\-group differences was verified using the Mann\-Whitney or Kruskal\-Wallis tests, respectively. The Spearman’s rank correlation coefficient was used in testing the strength of relationships between particular variables. While comparing the incidence of microorganisms, the author also employed tests serving for comparing two or more structural indicators. Statistical significance was established at p<0.05. The hypotheses were verified at 0.05 \(significant\), 0.01 \(very significant\) and 0.001 \(highly significant\). Based on the results, the author concluded that in the years 1996\-2005, the most common strains observed in burn wounds in children included MSCNS, Enterococcus faecalis, MRCNS, Pseudomonas aeruginosa and Acinetobacter baumannii. Positive mycological cultures accounted for 5.8% of all positive microbiological cultures of materials originating from burn wounds. Yeast\-like fungi were predominantly isolated, including Candida spp. With a growing time interval after the injury, the microbiological profile of the burn wound changed in the following way\: in the first two days, the predominant strains included MSCNS, MSSA and Enterococcus faecalis \; between 3\-7 days \- MRCNS and Enterococcus faecalis \; between 8\-14 days \- MSCNS, Enterococcus faecalis, MRCNS and Pseudomonas aeruginosa \; between 15\-21 days \- MSCNS, Enterococcus faecalis, Acinetobacter baumannii and Pseudomonas aeruginosa, and after more than 22 days after thermal injury, the most commonly isolated strains included MSCNS, Corynebacterium sp., MRCNS, Pseudomonas aeruginosa and Acinetobacter baumannii. Yeast\-like fungi were present in the burn wound starting in the second half of the first week of burn disease, and starting from the fourth week, they predominated in mycological cultures. Mould fungi were noted in week 2 and 3 following the injury. Treatment protocols did not affect the relative frequency of isolating the majority of bacteria. The exception was Acinetobacter baumannii strains, which were present solely in patients treated by early \(day 1\-7\) burn wound excision followed by grafts \(p<0.05\), as well as Pseudomonas aeruginosa, which was seen more frequently \(p<0.05\) in patients treated according to the above protocol."]

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