Search for: [Abstract = "The invented path of synthesis started with the connection of chiral synthon \- 4\-\(2,3\-epoxypropyl\)morpholine \(2\) to 8\-bromotheophylline \( 1 \). The synthon was received m reaction of morpholine with enantiomers of epichlorohydrin. Connecting the epoxide derivative to C\-7 position of methyloxanthine results in chiral oxazolopurine \- 7\-\(morpholinomethyl\)\-6, 7\-dihydrooxazolo\[2,3\-f\]purine\-2,4\(1H,3.H\)\-dione \(3\). The subsequent reaction with ammonia gives the desired product\-8\-amino\-7\-\[2\-hydroxy 1\-3\-\( morpholin\-4 yl\) propyl\]theophylline \(4\). The proposed method let to obtain 77 and 79 percentage of \( \+\) and \(\-\) enantiomers \(4\), respectively. The synthesis by using of another synthon \- glycidyl p\-toluenesulfonate does not succeed. The pharmacological tests revealed that the both enantiomers 8\-amino\-7\-\[2\-hydroxyl\-3\(morpholin\-4\-yl\)propyl\]theophylline \(4\) exhibit hypothensive activity. lt has been shown that this activity is not linked with the affinity to adrenergic receptors nor spazmolitic activity. During the reaction of 8\-bromotheophy lline \(1\) with 4\-\(2,3\-epoxypropyl\) morpholine \(2\) an interesting rearrangement occur\: the obtained oxazolopurine \(3\)is transformed to an isomeric compound 7\-\(morpholino \)\-7 ,8\-dihydro\-6H\-\[ 1,3 \]oxazino \[2,3\-f\]purine\-2,4\(1H,3H\)\-dione \(5\)."]

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