Search for: [Abstract = "The inflammation, which is a response of tissuesto damaging agents is a natural adaptive process in thehuman body. However, chronic inflammatory process canbe associated with the pathogenesis of cardiovasculardisease, cancer and metabolic syndrome.The purpose of this research aims to determinedpotential anti\-inflammatory properties of biomass extractsfrom in vitro cultures of selected edible mushrooms\:Imleria badia − bay bolete, Cantharellus cibarius − goldenchanterelle and Agaricus bisporus − white bottommushroom. These popular mushroom species are a richsource of phenolic and indole compounds, unsaturated fattyacids and bioelements with anti\-inflammatory activity.To investigate the anti\-inflammatory effect of the testedextracts several cell lines\: RAW 264.7, A549 and CaCo\-2were used. The effects of mushroom extracts on theexpression of inflammatory markers, such ascyclooxygenase\-2 \(COX\-2\), prostaglandin E \(cPGES\),glutathione S\-transferase \(GSTM1\), FP\-receptor protein,interleukin\-6 \(IL\-6\), and transcriptional factors PPARγ,NF\-ĸB and Nrf2 were analyzed.The tested extracts showed anti\-inflammatory activityin the used in vitro models. Received results showedsignificant inhibition of inflammatory markers caused bytested extracts from I. badia, C. cibarius and A. bisporusand also a stimulatory effect on the nuclear factor Nrf2\-dependent detoxification processes. Additionally, obtai"]

Number of results: 1