Search for: [Abstract = "The first part of the dissertation describes in vitro studies of the functional profile for new selective 5\-HT1A receptor ligands. For the first time, they included the parallel characterization of several dozen 5\-HT1A receptor ligands in several signaling pathways \(cAMP inhibition, ERK1\/2 phosphorylation, Ca2\+ mobilization, β\-arrestin recruitment\), which resulted in a pioneering discovery of numerous and diverse functional profiles. Ligands with higher than before functional selectivity for ERK1\/2 phosphorylation have been described, as well as for the first time ligands with a clear preference for β\-arrestin recruitment. In vivo studies investigated the potential antidepressant properties of four selected 5\-HT1A receptor biased agonists, both in the basic forced swimming test in mice and, for the first time, for such ligands, in murine models of corticosterone\-induced depression and unpredictable chronic mild stress. The tested compounds showed significant activity after a single administration, which distinguishes them from the currently available antidepressants, and the behavioral effects were correlated with favorable changes in the level of pERK1\/2 in the frontal cortex and hippocampus. The impact of the tested compounds on the consolidation process of memory traces in the novel object recognition test was also assessed."]

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