Search for: [Abstract = "The first mention about uterine fibroids dates back to the time of Hippocrates. However, there are stili wide gaps in the understanding of their pathogenesis. No single theory explains the background of the oldest uterine pathology, which affects more than 50% of women worldwide. By contrast, a newly depicted cell type called telocyte was only recently identified in the past twenty years. The unique features of telocytes coupled with experimental evidence from numerous studies lead us to create new hypotheses of the uterine fibroid pathogenesis. The results of current research will be discussed in our thesis. We explored the important telocytes interactions in the context of the uterine fibroid architecture. Telocytes not only internet with a variety of histological structures but have been the first line cells respond to hypoxia, thereby attracting our attention. The aim of the study was to identify uterine telocytes in the foci of fibroids and elucidate their role in fibrosis development, loca\] angiogenesis, and autonomie nerves interplay. Firstly, we performed the primary identification of telocytes using immunolabelling with further markers\: c\-kit, CD34, PDGFRa, tryptase. Jmmunofluorescent labeling was also used for all samples\: the corpus and uterine cervix \(exo\- and endocervix\) as well as leiomyoma foci. The use of mast cell tryptase staining enabled c\-kit\-positive mast c"]

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