Search for: [Abstract = "The effectiveness of treatment of hypertension is low. The guidelines can be supplemented with \"pathophysiological approach\" to an individualized therapy.The objectives\:\-examination of the relationship between plasma renin activity \(PRA\), aldosterone and asymptomatic organ damage \(AOD\)\-exploring the effect of antihypertensive treatment, consistent with Laragh and Alderman hypothesis, on blood pressure and AOD\-evaluation of clinical and biochemical discrepancies among patients from low\-renin and high\-renin groups with particular reference to the values of serum lipidsOperating range\: a planned prospective trial that included a total of 95\-122 patients with first or second\-degree hypertension.Conclusions\:\-the study of the effect of the renin\-angiotensin\-aldosterone system \(RAAS\) on the occurrence of AOD should include the relationship between the concentration of aldosterone and renin\-PRA as the only indicator has no predictive value for the occurrence of AOD, on the other hand an aldosterone\-to\-renin ratio \(ARR\) does have it\-the choice of antihypertensive drug based on PRA does not determine either the magnitude of the blood pressure reduction nor thesignificance of the AOD regression\-patients with high\-renin hypertension are characterized by higher serum total cholesterol and LDL\-cholesterol, but the relationship between LDL\-cholesterol and PRA is only in the low\-renin group."]
