Search for: [Abstract = "The duration of psoriasis had a strong positive correlation with aortic PWV. Left ventricular diastolic diameter \(LVIDd\) in echocardiographic examination for whole psoriatic group was significantly higher than in control group \(52,8±1,06mm vs 50,0±1,04mm, p<0,01\). LVIDd in psoriatic arthritis patients with SCORE rate over 5% and patients with psoriasis vulgaris with SCORE rate below 2% was higher than in control groups with the same SCORE rates. The values of left ventricular ejection fraction \(EF\) for all patients in psoriatic and control groups were in normal range and on the same mean level. Mean value of left ventricular mass index \(LVMI\) in whole psoriatic group was higher than in control group \(111,82±7,16 g\/m² vs. 92,8±7,07 g\/m², p<0.01\), but for all patients it was not over the normal range. Mean value of left atrium systolic diameter \(PL\) view was significantly higher in whole psoriatic group than in control group \(41,8±1,7 mm vs. 33,9±1,7mm, p < 0,0001\). Mean values of PL for psoriatic subgroups were over normal range \(40 mm\). Among parameters describing left ventricle diastolic function only E\/A ratio was lower in psoriatic group than in control group \(1,16±0,1 vs. 1,41±0,1, p<0,01\).The lowest values of E\/A were observed in psoriatic arthritis group with SCORE rate over 5%. Psoriatic patients \(whole group\) had wider ascending aorta \( AoD\) than control group \(34,37±0,91mm vs 29,95± 0,9mm, p<0,001\). The prevalence of mitral regurgitation \(MR\) in psoriatic patients was higher than in control group \(67 % vs. 17 % , p< 0,05\). The highest prevalence of MR characterized the group of patients with psoriatic arthritis with SCORE rate over 5%. Serum level of IL\(interleukin\)\-18 among psoriatic patients was higher than in control group \(219,63±10,25 pg\/mL vs. 164,25±10,25 pg\/mL\). For psoriatic patients significant positive correlations between IL\-18 level and interventricular septum \( IVSd\) and left ventricle posterior wall diastolic diameter \(LVPWd\) were observed. Significant negative correlations in this group were observed between IL\-18 level and EF as well as E\/A ratio. Plasma concentration of tumor necrosis factor α \(TNFα\) in psoriatic patients was higher than in control group \(2,5±0,12 pg\/mL vs. 2,05±0,12 pg\/mL\). Among patients with psoriasis and AR serum level of TNFα was significantly higher. For whole psoriatic group serum level of IL\-6 was higher than in controls \(2,44±0,32 pg\/mL vs.1,11±0,32 pg\/mL\). Among psoriatic patients significant negative correlation between IL\-6 level and E\/A was observed. IL\-12 among psoriatic patients was lower than in control group \(0,85±0,16 pg\/mL vs.1,52±0,16 pg\/mL\). IL\-12 level correlated negatively with AoD in psoriatic patients. Serum levels of interleukin 4 and 10 were decreased in psoriatic patients but not significantly. IL\-10 level correlates positively with LVPWd and negatively E\/A ratio. Conclusions\: 1. When considering typical parameters used in cardiovascular risk stratification i.e age, gender, blood pressure, smoking\; psoriatic patients did not differ from non psoriatic, although they have higher plasma levels of total and LDL cholesterol. 2. Aortic pulse wave velocity and left ventricular mass index parameters related with increased cardiovascular risk were higher among psoriatic than in non psoriatic patients. Moreover studied psoriatic group was characterized by wider ascending aorta diameter, worse left ventricle diastolic function, enlarged left atrium and higher prevalence of mitral regurgitation. 3. Higher levels of interleukin 18, TNFα and interleukin 6 in the psoriatic than in the control group should be considered as a markers of increased inflammatory activity. This observation confirms prevalence of Th1 type cytokines activity in psoriatic process. Decreased lymphocytosis and inceased number of basophiles in the blood smear among patients with psoriasis vulgaris complete the immunological characteristic of studied group. 4. Increased levels of IL\-18 and TNFα amon."]

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