Search for: [Abstract = "The doctoral dissertation is based on monothematic series of articles, which consists of 4 original papers and review papers 1 with a total value IF = 6,073 and 85 points Ministry of Science and Higher Education.The studies regarding NGAL in serum and urine and Ang\-2 in serum included 65 patients diagnosed with AP hospitalized and treated in Surgical Ward of District Hospital in Sucha Beskidzka.In the publication on microRNA, the studied group consisted of 88 patients, including 65 treated in Surgical Ward of District Hospital in Sucha Beskidzka, and 23 hospitalized in Surgical Ward of Clinic of General, Oncologic and Gastroenterologic Surgery of University Hospital in Krakow.Characteristics of the papers included into PhD thesisArticle no 1 published in Przegląd Lekarski 2015\;72\(5\)\:1\-5 is an introduction into the thesis, which guides through the issues related to AP. The article presents definition of AP, and describes in details the prognostic scales and laboratory biomarkers useful in early phase of the disease. Basic data from world literature relevant to biomarkers studied in this thesis \(NGAL, Ang\-2\) were also summarized.Article no 2 published in Mediators of Inflammation \(Doi\: 10.1155\/2016\/5780903\) evaluates the usefulness of angiopoetin\-2 \(Ang\-2\) serum concentrations for prognosis of severity of AP and early diagnosis of complications, especially acute kidney injury \(AKI following KDIGO\) and renal failure recognized on the basis of Marshall score. Correlations were reported between Ang\-2 concentrations and laboratory indicators used for monitoring the course of AP, including markers of renal function.Article no 3 published in Folia Medica Cracoviensia 2016\; 56\(2\) deals with diagnostic usefulness of sNGAL in recognition of SAP in early phase of the disease. The paper shows how sNGAL concentrations change depending on the severity of the disease, and reports correlations between sNGAL and BISAP score and certain markers of inflammation. Also, the prognostic value of sNGAL was estimated.Article no 4 published in Folia Medica Cracoviensia 2016\; 56\(1\)\: 13\-25 compares the diagnostic utility of urine and serum NGAL concentrations in early phase of AP. Particularly, the usefulness of these measurements in prediction of AKI complicatingAP was evaluated. Correlations were reported between uNGAL, sNGAL and markers of kidney function \(urea, creatinine, albuminuria\)."]

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