Search for: [Abstract = "The determination of antidepressant\-like activity of magnesium in the chronic mild stress and olfactory bulbectomythe animal models of depression was the main objective of these studies. Studies were conducted on Wistar male rats \(chronic mild stress\) and Sprague\-Dawley male rats \(olfactory bulbectomy\). The antidepressant\-like activity of magnesium in the chronic mild stress model was measured in the sucrose solution intake test. For evaluation of antidepressant\-like activity of magnesium in the olfactory bulbectomy model the passive avoidance and open field tests were used. The expression of chosen proteins and mRNA of molecules' engaged in the functioning of glutamate system were determinated respectively by western blotting and RT\-PCR methods. Magnesium at a dose of 15mgMg\/kg reversed reduction in the sucrose solution intake evoke by chronic mild stress after 3 weeks of treatment. Administration of magnesium at doses of 15 and 20 mgMg\/kg significantly improved ability to acquisition of passive avoidance reflex in OB rats. In the open field test all used doses \(10, 15 i 20 mgMg\/kg\) of magnesium reduced hyperactivity induced by bulbectomy. After chronic mild stress increased levels of GluN 1 subunit of NMDA receptors and GluA 1 subunit of AMPA receptors in amygdala were observed. These changes were accompanied by elevated level of BDNF. All of these alterations were reversed b"]

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