Search for: [Abstract = "The aim of this study was to determine the potential antidepressant activity of 20 pipreazine derivatives, to determine their mechanism of action and other pharmacological properties and to investigate the relationship between the structure and activity. 6 compounds \(HBK\-1 \(R, S\), HBK\-1 \(S\), HBK\-1 \(R\), HBK\-10, HBK\-14 and HBK\-15\) with high affinity for 5\-HT1A and α1 receptors and strong antidepressant\-like effect in Porsolt test \(FST\) in mice have been selected for extended studies. Antidepressant\-like activity of most compounds was confirmed in tail suspension test in mice. Possibly the mechanism of action of tested compounds is related to their agonism for 5\-HT1A receptor. Moreover, compounds HBK\-14 and HBK\-15 showed anxiolytic\-like properties. None of the tested compounds at the lowest dose active in FST in mice had any effect on normal rat ECG. All compounds decreased blood pressure in rats, which may be due to their α1\-adrenolytic properties. The study showed that the strongest effect in the group of xanthone derivatives had compounds with 2\-methoxyphenylpiperazine moiety in position 4 of xnathone, and among aroxyalkyl derivatives of 2\-methoxyphenylpiperazine, compounds with a chlorine atom in phenoxyl moiety. In addition, S isomer of compound HBK\-1 \(R,S\) showed stronger antidepressant\-like effect and lower toxicity than racemat and R isomer."]

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