Search for: [Abstract = "The aim of this study was to analyse clinical and molecular prognostics factors in resettable pancreatic cancer. One hundred and sixty\-five patients underwent pancreatic resections between 1975 and 2004, including 103 \(62%\) males and 62 \(38%\) females \(mean age 60.4 ±8.7 years\). Of 101 tumours subjected to immunohistochemical tests, positive staining was identified for the following proteins\: p53 \- 71 %\; Bcl\-2 \- 31 %\; Bax \- 90%\; Bel\-X \- 79%\; Bak \- 25%. The presence of p53 was associated with poorer differentiation and a higher stage of the primary tumour. Bel\-2 protein was related to lower staging, absence of lymph node metastases, and a higher proportion of tumours limited to the pancreas. No statistically significant correlations could be identified for Bel\-X, Bax and Bak immunoreactivity and various parameters of the tumour. The median survival was 14.8 months and the 5\-year survival was 14.3%. Of all analysed proteins, expression of p53 and Bel\-X significantly correlated with poor survival. The following independent negative prognostic factors were identified with the Cox proportional hazards model\: moderate or poor differentiation \(G2\/G3\), metastases to regional lymph nodes, the percentage of metastatic lymph nodes > 15%, blood vessels involvement, infiltration of superior mesenteric artery or coeliac trunk, and microscopic or macroscopic residual tumour."]

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