Search for: [Abstract = "The aim of this study was the development and optimization of the composition of orodispersible films \(ODFs\) and the process of their preparation with various methods, i.e. solvent casting, electrospinning and 3D printing, as well as the assessment of their quality. For this purpose, 40 series of the ODF films including 14 placebo formulations and 26 series containing raw aripiprazole or in the form of solid dispersion, were prepared and assessed. The results of the studies show that the properties of the ODF films depended on their composition and the applied production technology. Due to the poor water solubility of aripiprazole, the solid dispersions with polymeric carriers such as Poloxamer® 407, Kollidon® VA64, mannitol, Macrogol 6000, or Soluplus® were prepared using a ball milling method. Among the analyzed carriers, the Poloxamer 407 had the best properties. Therefore, the aripiprazole\-Poloxamer® 407 \(1\:1\) solid dispersions were prepared for further studies. The next stage of the research included optimization of the ODFs composition and the process of their preparation. In the case of ODF films prepared by the casting method, the PVA\-based films with 15% glycerol addition were the most suitable for the preparation of ODF films, due to their better mechanical properties and shorter disintegration time. Moreover, ODFs with solid dispersion showed a smoother films surfa"]

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