Search for: [Abstract = "The aim of this study was application of meglumine as a carrier in solid dispersions pellets containing poorly water soluble drugs. Three drugs were selected as a model\: ketoprofen, piroxicam, indomethacin. The melting method and spray\-drying method were used to prepare solid dispersions. The properties of meglumine solid dispersions were depended on the method of preparation, the drug\/meglumine ratio and properties of the drug. It was found, that melting method was appropriate to obtain solid dispersions of good quality for all drugs. The spray–drying method was suitable for preparation piroxicam and indomethacin meglumine solid dispersions. The best results were obtained for ketoprofen solid dispersions\: \(1\+0.5\), \(1\+1\) prepared by melting method and for spray\-dried indomethacin solid dispersions \(1\+0.5\), \(1\+0.25\). Three kinds of pellets were prepared by extrusion\/spheronisation\: containing the drug alone, solid dispersion or physical mixture. The pellets formulation was based on the results of rheological behaviour of wet powder mass which was assessed by using the compresso\-rheometer. The present work has demonstrated the improvement of rheological properties of mass for extrusion in the presence of meglumine. Formulations composed of microcrystalline cellulose\-lactose\-meglumine in the ratio \(7\+3\+0.4\) and \(7\+3\+0.5\) showed the best rheological properties. Pellets prepared fro"]

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