Search for: [Abstract = "The aim of this doctoral study was evaluation of hypotensive and pleiotropic activity of tested compounds after chronic administration in the selected experimental models of hypertension. Seven compounds with α1\-adrenolytic activity were selected for tests, three of which were xanthone derivatives \(MH\-2, MH\-3 and MH\-99\) and others four were pyrrolidin\-2\-one derivatives \(EP\-46, EP\-47, EP\-49 and EP\-58\). The main aim of this study required validation of four different animal models of hypertension\: DEX model, DOCA model, FRU model and L\-NAME model. This last one – L\-NAME model – met all assumptions of this study and was selected to evaluation of potential pleiotropic activities of tested compounds. All of tested compounds were evaluated in L\-NAME model after chronic administration in terms of their potential hypotensive activity, influence on relaxation of isolated rat\-aorta, on glucose and lipid plasma levels, on oxidative stress parameters, on NO2\- and NO3\- plasma levels, and also on two circulatory biomarker plasma levels – ADMA and VEGF. At the end intrinsic activity for tested compounds towards human α1A\-, α1B\- and α1D\-adrenoceptors was also evaluated. Compounds marked with symbols MH\-2, MH\-3 and MH\-99 showed high therapeutic activity in all pharmacological and biochemical studies. Additionally, these compounds showed also high preferential α1D\-adrenolytic activity. These results suggest that α1D\-adrenolytic activity of tested compound may be connected with their hypotensive activity and with their corrective influence on disturbed endothelium function induced in L\-NAME hypertension model."]

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