Search for: [Abstract = "The aim of the study were\: to define the prevalence of diabetic retinopathy in patients with T2DM from the Polish population\; to analyze the clinical features associated with this complication and to search for association between the Pro12Ala amino acid variant in the PPAR\[gamma\] gene, the G\-A substitution in the 4852 position of the calpain 10 gene \(SNP43\), and two polymorphisms in protein tyrosine phosphatase\-N1 \(PTPN1\) gene\: rs3787345 \(substitution T\-C\) and rs754118 \(substitution C\-T\) and DR in T2DM. Materials and methods\: The study group consisted of 359 T2DM. The diagnosis of DR was based on the ophthalmologic examination after the pupillary dilatation. Biochemical factors were also measured. The subjects were genotyped for markers\: Pro12Ala of PPAR\[gamma\], SNP43 of calpain 10, rs3787345 and rs754118 of PTPN1. Results\: The mean age examined patients was 60.8 \+\/\- 9.7 years, T2DM duration\: 11.2 \+\/\- 7.0 years, body mass index\: 31.3 \+\/\- 7.4 kg\/m2. Diabetic retinopathy was detected in 33.7%. Among the patients with diabetes duration below 10 years retinopathy was diagnosed in 18.3% \(n=33\) patients, while in the sub\-group with diabetes duration between 10 and 20 years retinopathy was present in 43.7% \(n=52\) of T2DM individuals. In the group of patients with the longest history of diabetes \(above 20 years\), retinopathy was observed in 62.5% \(n=35\) subjects. The multivariate anal"]

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