Search for: [Abstract = "The aim of the study was to select from among 43 arylsulfonamide derivatives of \(aryloxy\) alkylamines, uroselective structures with the highest preference for subtypes A and D of α1\-adrenoceptor \(AR\), which would provide the basis for further studies of these compounds as candidates in the treatment of prostatic hyperplasia.Pharmacological screening included the determination of α1\- and α2\-AR affinities and intrinsic activity for α1A and α1B \-AR. Four structures were identified\: PZ \- 962, PZ \- 1204, PZ \- 1205 and PZ \- 1206, which were passed on to further research, including the determination of intrinsic activity for α1D\-AR and antagonistic activity against α1A, α1B and α1D\-AR in biofunctional studies. Subsequently, hypotensive activity after single iv. and chronic ip. administration in rats, the effects on pressure activity elicited by methoxamine, plasma carbohydrate\-lipid profile, normal rat electrocardiogram and cholinolytic activity were evaluated.Finally, there were identified structures with significant α1\-adrenolytic activity and beneficial influence on lipid\-carbohydrate parameters, demonstrating no relevant effects on cardio\-vascular system. Selected compounds showed no higher binding preference for α1A\/D\-AR than tamsulosin, neither cholinolytic activity. Although weaker receptor activity of selected compounds was found in comparison to tamsulosin, the final confirma"]

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