Search for: [Abstract = "The aim of the study was to evaluate the serum concentration of selected cytokines\- tumor necrosis factor alfa \(TNF\-alfa\), interleukin 2 \(IL\-2\) and soluble interleukin 2 receptor \(sIL\-2R\) in children with primary nephrotic syndrome \(NS\) in different disease stages and the correlation with particular clinical and biochemical parameters. The prognostics of cytokines concentrations for progression of morphological changes and for treatment results, especially with Cyclosporine A \(CsA\), were evaluated. 98 children with primary NS, aged 1\-16,5 years, 56 boys and 42 girls, treated in the Dpt. of Pediatric Nephrology, were enrolled into the study. Cytokines were determined in 141 relapses of NS and in different stages of remission. The kidney biopsy was made in 51 patients, and repeated in 22. The control group consisted of 31 healthy children aged 0,6\-16,5 years, 18 boys and 13 girls. The TNF\- alfa and sIL\-2R concentrations were determined by ELISA kits and IL\-2 by EIA kits. TNF\- alfa serum concentration increased in NS relapse and depended on clinical and biochemical status. The risk of glomerular sclerosis was higher with increased TNF\- alfa concentrations. IL\-2 concentration increased in NS relapse, decreased gradually in remission, and correlated with lipids and immunoglobulin G levels. Patients with low IL\-2 concentrations showed higher proportion of staying in remission in the"]

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