Search for: [Abstract = "The aim of the study was\: 1\/ to evaluate the usefulness of HRCT\-score as a guide method in selection of the most reliable lung region for VATS biopsy in DPLD, 2\/ to examine the correlation between HRCT\-score and semi\-quantitative histopathological results in idiopathic interstitial pneumonias \(IIPs\) based on HP\-score, 3\/ to evaluate the homogeneity of fibrosis by estimation of cytological and immunological results of TGF\-ß1, MMP\-9, PGE2 and PGD2 in double BAL from two different lung segments\: with the most and with the least extensive involvement estimated by HRCT\-score. Examined group consisted of 31 patients in whom diagnosis of DPLD was not established by clinical, radiological, physiological and non\-invasive methods. The two different lung segments were indicated by HRCT\-score for BAL and VATS biopsy. Regarding as histopathological results there were 17 IIPs and 14 granulomatous diseases \(GDs\). Twenty eight of patients showed nonhomogenous distribution of HRCT changes, with a predominance of linear opacities in IIPs in lower lobes \(p = 0,05279\) and higher HRCT\-score in IIPs in lower lobes \(p < 0,01\). In IIPs the odds ratio for obtaining better histopathological result was 12,5\-times higher depending on higher activity in HRCT\-score, also confirmed by logit model \(p = 0,0609\). In GDs the histopathological result was obtained in 84,62%, independently of HRCT\-score and with no predilection for any lobe. A semi\-quantitative histopathological result in IIPs is correlated only with few parameters of HRCT\; a fibrosis\-score with linear opacities \(χ2 p = 0,042\) and a cellularity\-score with intensity of changes \(χ2 p = 0,0192\) and ground\-glass opacities \(χ2 p = 0,026\). There was not found any correlation between total HRCT\-score and HP\-score. A higher amount of neutrophils and eosinophils and a higher concentration of TGF\-ß1, MMP\-9 and PGD2 in BAL may occur good markers of fibrosis in IIPs, but only the higher concentration of TGF\-ß1 \(p = 0,018\) and the higher amount of eosinophils \(p = 0,016, ANOVA\) are significantly correlated with HRCT\-score."]

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