Search for: [Abstract = "The aim of the present studies was the evaluation of the analgesic activity of some 3\-substituted γ\-butyrolactone derivatives and their amide counterparts. Some of the experiments aimed to elucidate the mechanism of analgesic activity of the investigated compounds. In the introductory part of the dissertation thesis the nociceptive process was described. The modulatory role of transmitters \( e.g. excitatory ammo acids, substance P, prostanoids, ATP, GABA, opioids\) and ion channels was discussed, as well. In the experimental part study design and obtained results were described and precisely discussed. The screening tests included the activity of the investigated substances m acute \(hot plate, writhing and capsaicin\-induced\) and tonic pain models in mice. Spontaneous locomotor activity and acute toxicity were assessed, too. The most active compounds were additionally tested in guinea pigs for their local anaesthetic activity \(infiltration and corneal anaesthesia\) Moreover two most active lactones were tested for their interaction with serotonergic, glutamatergic and endocannabinoid systems. On the basis of the experiments it was established that 3\-substituted phenylpiperazine derivatives of γ\-butyrolactone are highly antinociceptive and this effect is not a consequence of their receptor affinity \(GABAergic type A, B, adrenergic α2, opioidergic μ or serotonergic 5HT1A\). Neither d"]

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