Search for: [Abstract = "The Tgαq\*44 mice exhibit a unique animal model of HF in which the overexpression of active αq subunit of the G protein in cardiomyocytes mimic persistent receptor \(adrenergic α1,angiotensin AT1, endothelin ET\-A\) stimulates and activates the intracellular signal pathways. These intracellular pathways are known to play key roles in the pathogenesis of the heart hypertrophy and cause heart failure in humans. The purpose of this study was to assess the effect of two month therapy with angiotensin\-converting enzyme inhibitor \(ACE\-I\) and aldosterone receptor antagonist \(ARA\) on left ventricle functions in Tgαq \*44 mice. In the course of this study, the ACE inhibitor \(perindopril\) and aldosterone receptor antagonist \(ARA\) were used in early \(10\-12 month old\), advanced \(12\-15 month old\), and end \(15\-17 month old\) stage of heart failure in Tgαq\*44 mice. The systolic and diastolic functions of left ventricle were evaluated before and after therapy using magnetic resonance imaging \(MRI\). Additional dobutamine stress tests were performed for the assessment of cardiac reserve in the end \- stage HF . The heart failure progression in Tgαq\*44 mice was also assessed by morphometric parameters \(ventricular weight\), biochemical parameters \(level of BNP, aldosterone\). Based on parameters obtained from MRI and LV time – area curve following parameters of cardiac function were assessed\: end\-diastoli"]
