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Search for: [Abstract = "TAFI antigen remained unaltered during stress test in the AS group. Interestingly, in all four time points, TAFI activity was higher in ASgroup than in controls \(all p<0.001\). In AS patients TAFI activity remained unaltered at peak exercise, but then after a decrease after one hour it rose above the baseline value \(p=0.003\). In controls TAFI activity was reduced during the test and after its completion compared to the baseline \(all p<0.01,\). Of note there was a weak association between TAFI antigen and Vmax \(r=0.36, p=0.042\). Importantly, in AS patients CLT at baseline, but not in three other time points, correlated with TAFI activity \(r=0.69, p<0.001\), α2\-AP \(r=0.47, p=0.007\) and plasminogen \(r=\-0.55, p=0.001\). In controls CLT correlated with TAFI activity in all time points \(r=0.65, p<0.001\; r= 0.54, p=0.001\; r=0.42, p=0.015\; r=0.50, p=0.003, respectively\).Plasminogen was similar at baseline in both groups, but then plasminogen became higher in AS group \(all p<0.05, respectively\). There were no differences in PAI\-1 antigen between the two groups in any time point. Although α2\- antiplasmin remained unaltered during exercise test in the AS group, it was higher than in the control group at baseline \(p=0.024\), similar at peak exercise, and lower at one and 24 hours post exercise \(both p<0.05\). Importantly, in AS patients CLT at baseline, but not in three other time points, correlated with TAFI activity \(r=0.69, p<0.001\), α2\- antiplasmin \(r=0.47, p=0.007\) and plasminogen \(r=\-0.55, p=0.001\). In controls CLT correlated with TAFI activity in all time points \(r=0.65, p<0.001\; r=0.54, p=0.001\; r=0.42, p=0.015\; r=0.50, p=0.003, respectively\).Soluble TM in both groups at baseline was similar, but it was higher than in the control group both at peak exercise \(p<0.001\), one \(p<0.001\) and 24 hours after exercise \(p=0.034\). Pre\-exercise CLT, but not other fibrinolytic variables, correlated with TM in the AS group \(r=0.55, p=0.001\).There were no differences in tPA antigen between the AS and control groups.There were no intergroups differences and post\-exercise changes in troponin levels in both.The current study shows that during exercise moderate\-to\-severe AS patients display a specific pattern of prothrombotic changes in coagulation and fibrinolysis markers, quite different from that observed in age\- and sex\-matched controls. Patients with AS respondto physical activity with a marked increase in maximum concentration of thrombin generated and a decrease in fibrinolytic capacity. The present data suggest that exercise\-induced prothrombotic alterations in AS patients may promote fibrin deposition on aortic valve leaflets, leading to the progression of this disease. It might be speculated that intense exercise could contribute to faster progression of valvular lesions and higher risk of cardiovascular events. Our observations apply to patients with moderate\-to\-severe AS, and cannot possibly be extended to the early stages of this disease."]

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