Search for: [Abstract = "Studies on the biotransformation of drugs were carried out using laboratory animals from the eighties of the last century. According to the European Centre of the Validation of Alternative Methods in various tests up to 10 million animals per year are killed, more than 60 % of these \- in the preclinical phase of drug testing. Apart from humanitarian reasons, economic considerations, time and only 50 % chance to reflect the results obtained in animal models in later studies involving people are the other aspects against in vivo studies . Especially in the early stages of drug development alternative methods are more relevant and appropriate . These models meet the criteria introduced by Russell and Burch called 3R criteria \(replacement, reduction, refinement\). In silico and in vitro biotransformation studies, which include research using microorganisms and liver subcellular fractions are complient with 3R principle.The project conducted within the doctoral thesis applied research on the biotransformation of twelve selected structure obtained in the Department of Bioorganic Chemistry, Chair Organic Chemistry and in the Department of Medicinal Chemistry, Chair Pharmaceutical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College. Selected structures had proven activity in the central nervous system in animal models. Among the compounds investigated were aminoalkan"]

Number of results: 1