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Search for: [Abstract = "Somatostatin receptor scintigraphy \(SRS\) is widely used in imaging of gastroenteropancreatic neuroendocrine tumours \(GEP\-NET\). In this study the usefulness of 99mTc\-EDDA\/HYNIC\-TATE was analysed in detection of GEP\-NET and pheochromocytoma in comparison to 111In\-Octreoscanem and 131I\-MIBG. Sensitivity and specificity of SRS and CT were also compared. 93 patients were examined \(51.2±16.2 y\)\; 77 with GEP\-NET \(50 with carcinoid and 27 with GEP\-NET of pancreas\) and 16 with pheochromocytoma. SRS with 99mTc\-EDDA\/HYNIC\-TATE \(740 MBq\; WB\- 10 min, 4, 24h\; SPECT\- 4h\) and abdomen CT were performed in all patients. In 15 patients with GEP\-NET 111In\-Octreoscan and in patients with pheochromocytoma 131I\-MIBG scintigraphy was performed. Focal lesions were better visible in 99mTc\-EDDA\/HYNIC\-TATE SRS and target\/non\-target ratios were higher for hepatic and abdominal lesions. 99mTc\-EDDA\/HYNIC\-TATE SRS comparing to CT was more sensitive in detection of primary lesions and recurrences of GEP\-NET \(81.4% vs. 58.1%, p=0.01\) and of carcinoid \(78.3% vs. 47.8%, p=0.02\) and GEP\-NET hepatic metastases \(100.0% vs. 78.9%, p=0.03\). In patients with pheochromocytoma adrenal lesions presented higher target\/non\-target ratios in 131I\-MIBG scintigraphy but these ratios for metastases were higher in 99mTc\-EDDA\/HYNIC\-TATE SRS. Sensitivity of SRS was lower than CT in adrenal lesions imaging \(68.7% vs. 93.7%, p<0.05\). High quality images obtained with 99mTc\-EDDA\/HYNIC\-TATE make it an attractive alternative to 111In\-Octreoscan in diagnosis of GEP\-NET. It can also play an important role in visualization of pheochromocytoma metastases."]

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