Search for: [Abstract = "Since the end of the last century the adipose tissue has been considered as an organ of endocrine secretion. A number of key substances – adipokins are produced by the cells of the adipose tissue – adipocites, and the stromal vascular fraction of adipose tissue. They participate in integration and co\-operation of various tissues and supervise metabolic processes. The most important adipokins and cytokins are\: leptin, adiponectin, adipepsin, adipsin, resistin, interleukin 6 \(IL\-6\), inhibitor of plasminogen type 1 \(PAI\-1\) activator, TNF, angiotensinogen, as well as enzymes, such as aromatase. Aromatase \(P\-450 aromatase\) is the main enzyme of oestrogen synthesis in all vertebrates. Oestrogens synthesized in the presence of aromatase regulate the functions connected with sexual features and show a protective activity for the cardiovascular system. They also have pro\-carcinogenic activity in case of breast and endometrial cancers. There is a significant difference in aromatase expression in women depending on their age. In pre\-menopausal period the sites of aromatase expression are ovaries, whereas in postmenopausal period – the visceral and subcutaneous adipose tissue. Taking into consideration previously known the role of this enzyme in oestrogen production in females, the aim of this work was investigation of the difference in aromatase expression in the visceral and subcutaneous"]

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