Search for: [Abstract = "Searching for compounds with potential activity on cardiovascular system within the group of 7,8\- disubstituted derivatives of theophylline m the Department of Pharmaceutical Chemistry of Collegium Medicum of Jagiellonian University, we obtained new 7\-β\-hydroxy\- γ\-\(N4phenoxyethylpiperazine\)\-propyl derivatives. Initial pharmacological studies lead to the selection of 7\- β \-hydroxy\- γ \-\(N4\-phenoxyethylpiperazine\)\-propyltheophylline dihydrochloride \(CH\-1\), a compound that exhibits an antiarrythmic, hypotensive activity and an affinity for α1, and α2 \-adrenergic receptors. As a result of a modification of the compound CH\-1 consisting in the introduction of vanous arylalkylamino or aminoalkylamino substituents at the 8\-position of theophylline, as well as, by substituting phenoxyethylpiperazine by another piperazine group, seven active structures were obtained that exhibited comparable or higher antiarrythmic and\/or hypotensive effect and the affinity for α1 and α2\-adrenergic receptors than CH\-1 . The studies carried out allow us to state that the highest affinity for α1\-adrenergic receptors is demonstrated by compounds having a phenoxyethylpiperazine or phenylpiperazine group in their structure. The most advantageous for the antiarrythmic activity is the presence of the phenoxyethylpiperazine or phenylpiperazine group at the 7\-position of theophylline, and the 2\-morpholineethylamin"]

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