Search for: [Abstract = "Results All included patients presented symptoms with onset up to the endof the 1st year of age. Two patients were diagnosed during prenatalperiod. After birth the largest group constitute infants up to the end of6 weeks of age according to Ellams’ classification.Median time of duration of symptoms was 4 weeks. Because ofdifferences in duration of symptoms in some cases diagnosis wasmade after 12 months of age if symptoms appeared up to 12 months oflife. Median age of recognition was 32 weeks.The most common presenting sings in children up to 6 weeks of agewere macrocrania and those of increased intracranial pressure whereasin older children focal symptoms were more common. Nearly 60% ofall tumors were located in supratentorial compartment.Ultrasonography was the initial imagine study in 45%.The differences in time of the age of symptoms between high gradeand low grade tumors was statistically significant with prevalence ofhigh grade tumors during the first 6 months of life and low grade inthe period 6–12 months.Total resection was achieved in more than half of patients \(51,3%\)who underwent surgical intervention. Adjuvant treatment wasperformed in 38,1% of patients. Mortality was 40,5%. Taking intoconsideration differences in tumors location and histopathologic typethere was statistically significant higher mortality and survival in thecases located infratentorially and high grade tumors.The analysis of functional outcome after 1 and 5 years from diagnosisassessed with Lansky Performance Scale showed statisticallysignificant deterioration after 5 years that affected mainly patients whoreceived low score after 1 year, with high grade tumors located inposterior fossa and incompletely resected.ConclusionsCongenital CNS tumors have poor prognosis comparing to thosefind in other children both in respect of mortality and quality of life.The outcome of congenital CNS tumors depends the most on theextend of surgical resection, histopathological type and location of thetumor.The management in cases with fatal prognosis should includepossibility of ending the therapy in every stage of treatment from thetime of prenatal diagnosis until finish therapeutic possibilities."]

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