Search for: [Abstract = "Results\: The study group consisted of 138 parents \(57 men, 81 women\) and 165 descendants \(79 men, 86 women\). Average age of parents was 61.5 ± 7.9 years, and of descendants 34.8 ± 8.4 years. There were no significant differences between the groups in the values of blood pressure on ambulatory monitoring, except for the daytime diastolic blood pressure that was lower in parents \(75.4 ± 7.7 vs 77.4 ± 8.2 mm Hg, p <0, 05\). Mean urinary sodium excretion in parents was 175 ± 71 mmol \/ d, and the descendants’ group 161 ± 65 mmol \/ d and was not significantly different. No difference was found between serum VEGF\-C levels, nor between generations neither genders. Multivariate regression analyse were adjusted for age, gender, body mass index, use of antihypertensive drugs, declared smoking and alcohol consumption. In whole study group there was no association between serum VEGF\-C and blood pressure throughout 24 hours, daytime and nighttime. In subgroup analysis of participants never treated with antihypertensive medications there was observed a negative correlation between serum VEGF\-C and systolic \(β \[Beta \- regression coefficient\] \-0.0017, p=0.047\) and diastolic \(β \-0.0014, p=0.049\) blood pressure over 24 hours. Such relation was not shown for the population receiving antihypertensives. In the study population, there was no significant difference in the concentration of VEGF\-C levels between individuals with hypertension and normotensives. In univariate analysis there was demonstrated a significant, positive correlation between the concentration of serum VEGF\-C and the extracellular fluid volume \(r = 0.1897 p 0.0047\) as well as plasma concentration of aldosterone \(r 0.1406 p=0.0148\). This correlation was more pronounced in the subgroup of patients not treated with antihypertensives \(r 0.23623 p=0.003 and r 0.0148, p=0.0015\). Using stepwise regression analysis as the determinants of plasma VEGF\-C levels there were selected\: extracellular fluid volume \(r2 0.038, p=0.0047\), plasma aldosterone levels \(r2 0.0635 p=0.0123\) and plasma levels of myeloperoxidase \(r2 0.0752 p=0.0996\). The proposed model explained 7.5% of the observed variability in concentrations of VEGF\-C. In the study group, we did not observed any interaction between serum VEGF\-C, sodium excretion and blood pressure throughout 24 hours, daytime and nighttime. While analysing subgroup of participants never treated with antihypertensive medications we observed negative interaction between concentration of VEGF\-C and excretion of sodium and night\-time diastolic blood pressure \(β \-0.0014, p=0.049\)."]

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