Search for: [Abstract = "Recommendations of the US Food and Drug Administration regarding Process Analytical Technology, Quality by Design as well as recently introduced model\-informed drug development program, indicate the need to better understanding of factors affecting final product quality. All initiatives could be realized by the development of proper models, which could be applied at product development stage ass well as quality control at the production stage. Scientific assumptions of the doctoral dissertation concern the development of tools supporting research and development of inhaled drugs. They were implemented by constructing empirical models, capable of predicting the size of particles composed lactic and glycolic acid copolymers and particles deposition in vitro of carrier\-based formulations intended for inhalation. Additionally, models were applied to optimize the features of carriers particles in\-silico. The databases were compiled on the basis of literature data and the results of laboratory experiments carried out at the School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, which were delivered as part of the international research project “Delivery of Protein and peptide drugs through dry powder inhalation”, 2\/3\/POL\-SIN\/2012. Active pharmaceutical ingredients, as well as excipients included in the formulations, were encoded using molecular de"]
