Search for: [Abstract = "Recent studies have shown that ghrelin exhibits protective effect in the stomach and pancreas and accelerates the healing of gastric and duodenal mucosa. The aim of present study was to examine the influence of ghrelin administration on oral mucosa integrity and healing of chronic oral ulcers, as well as to evaluate the role of growth hormone and insulin\-like growth factor\-1 \(IGF\-1\) in these processes. Methods\: Studies were performed on three groups of animals\: \(1\) pituitary\- and salivary\-intact rats\; \(2\) sialoadenectomized rats with intact pituitary\; \(3\) hypophysectomized rats with intact salivary glands. Chronic ulcers of the gingiva and tongue were induced by acetic acid. After induction of ulcers, rats were treated intraperitoneally twice a day with saline or ghrelin \(4, 8 or 16 nmol\/kg\/dose\) for six days. Also animals without induction of ulcers were treated with saline or ghrelin \(8 nmol\/kg\/dose\) for six days. Results\: In animals with intact pituitary and salivary glands without induction of oral ulcers, treatment with ghrelin was without effect on oral mucosa morphology, mucosal blood flow or cell proliferation in oral mucosa. In rats with intact pituitary and salivary glands, administration of ghrelin, after induction of gingival and lingual ulcers, significantly increased healing rate of these ulcers. Ghrelin given at the dose of 8 or 16 nmol\/kg\/dose caused the stronge"]

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