Search for: [Abstract = "Pyruvate dehydrogenase complex \(PDH\) catalyses the oxidative decarboxylation of pyruvate to acetyl Co\-A. PDH complex plays an important role in carbohydrate and lipid metabolism. Mammalian PDH complex is regulated by covalent modification. A specific PDH kinase \(PDK\) catalyses phosphorylation of PDH which results in inactivation whereas a specific PDH phosphatase \(PDP\) converts dephosphorylation and reactivation of PDH complex. PDK is a major factor influencing PDH activity. It was established that PDK activity is modified by various groups of xenobiotics. One of them are polyphenols, ubiquitous compounds in plant and also in human diet. Current interest of biological activities of polyphenolic compounds is due to their antioxidant properties. It is established that numerous polyphenols also improve carbohydrate and lipid metabolism in mammals. However, precise molecular action of these compounds is still unclear. It was also never under investigation the determination of influence of polyphenols on PDH activity. This study investigated the influence of selected catechins\: catechine, epicatechine, kaffeic acid, qercetine, resveratrol and catechin\-3\-gallate on PDK activity in primary rat's hepatocytes culture. Liver cells were isolated from male rats and incubated with addition of different doses of catechins. Control hepatocytes were cultured under the same conditions without a"]

Number of results: 1