Search for: [Abstract = "Progressive renal dysfunction caused by the deposition of multiple myeloma\-derived monoclonal proteins is, apart from infections, the commonest cause of death in patients with multiple myeloma. There has been no convenient clinical method for easy prediction of the danger. Aggregation involves basically abnormal, structurally highly unstable proteins. A method for identifying the degree of polypeptide chain packing instability could meet this problem. This work proposes a simple electrophoretic technique using Congo red and newly synthesized Congo\-red derived dyes to disclose evident and discreet instabilities of myeloma proteins which may enhance the propensity to aggregate. Two basic protein instability levels, local and global, were differentiated by comparing the extent of protein loading with dye and the subsequent electrophoretic migration rate of the complexes."]

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