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Search for: [Abstract = "Premature thelarche \(TP\) is defined as isolated breast development in girls < 8 years of age, with no other signs of puberty onset. The aim of this study was to determine the role of kisspeptin\- KISS1R activation in ThP ethiopathogenesis.The study included 63 girls with TP \(3 months\-3,8 years\), that have been divided into three groups according to the Tanner staging.\: with unilateral \(group A\), with bilateral stage 2 \(Group B\), and with bilateral stage 3 \(group C\). The control group included healthy girls at the same age. Bone maturation, FSH, LH, TSH estradiol, testosterone, inhibin B, androstenedione, SHBG, kisspeptin levels, pelvic and breast USG were evaluated in both groups. No differences were found between the groups in the FSH, LH and estradiol levels. In patient group the uterus and the ovaries showed prepubertal sizes. Kisspeptin levels in both groups didn’t show statistically significant differences \(4.8 ± 2.81 vs 3.80 ± 3.21, p = 0, 22\). The kisspeptin levels in A, B, C groups were similar and didn’t depend on the Tanner stage \(4,5 vs 4,93 vs 4,9, p=0,94\). In patient group kisspeptin level showed a significant correlation with FCR \(ang.fundo\-cervical ratio\), \(r = 0.35, p = 0.004\). Similar correlations, kisspeptin with the uterine length \(r = 0.55, p = 0.018\) and kisspeptin with FCR \(r = 0.49, p = 0.038\) were in group B. These results would suggest direct action of kisspeptin without gonadotropins and estradiol."]

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