Search for: [Abstract = "Peroxisome proliferator\-activated receptors \(PPAR\) belong to a superfamily of nuclear transcription factors involved in the regulation of gene expression by direct interaction with DNA. Three types of PPAR proteins are currently known\: PPARa, PPARδ\/β and PPARγ. In spite of great similarity of their protein structure, subtle differences in amino acid sequence cause alterations in affinity of ligands for specific receptor types, and even selective binding of some of them the ligands only to one type of receptor. Among synthetic ligands of nuclear receptors, fibrates are strong agonists of PPAR. They are therapeutics that lower the concentration of plasma triglycerides concentration and correct lipoprotein level. Fenofibrate is a member of this group of compounds. Selective ligands of PPARδ\/β include\: L\-165041, GW\-501516 and carbacycline. Synthetic ligands of PPARγ are medications able to increase tissue sensitivity to insulin, belonging to thiazolidinedione group \(glitazones\) e.g. ciglitazone. They lower plasma glucose level in humans, and also reduce the amount of circulating free fatty acids. In recent years many interesting reports on anticancer potential of PPAR ligands were published. Melanoma still remains one of the cancers lacking due characterization in terms of molecular features. The reports published so far indicate that changes in the level and activity of trans"]

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