Search for: [Abstract = "Pancreatic gland located retroperitoneally accomplishes exocrine and endocrine function. The major components of neurohormonal system controlling pancreatic exocrine function include central nervous system with dorsal vagal complex DVC, the afferent \(sensory\) and efferent \(motor\) vagus nerves, the intrapancreatic ganglia, motor sympathetic nerves, enteric nerves as good as a number of hormonal substances such cholecystokinin, secretin, VIP, PYY, neurotensin, somatostatin, pancreatic polypeptide and others. Melatonin \(N\-acethyl\-5\- hydroxytryptamine\) is synthesized from its precursor, L\-tryptophan in four\-step process. Melatonin is produced in pineal gland, retina, ciliary apparatus, Harderian gland, respiratory epithelium, kidney and mostly in the gastrointestinal tract. Melatonin receptors have been detected in the liver, spleen, intestine and also in pancreatic beta cells. The results presented so far have been suggested that melatonin takes a part in the regulation of gastric and jejunal motor activity, as well as ion and electrolytes transport in the intestinal mucosa. The protective effects of melatonin on gastric ulcer and on the bowel diseases as good as oncostatic effects of that indoloamine in gastrointestinal tumours have been described. Administration of exogenous melatonin and also melatonin precursor, L\-tryptophan has revealed beneficent influence on the pancreatic"]

Number of results: 1